Arthritis

Researchers from Royal Melbourne Hospital describe findings in arthritis

Published in Blood Weekly, January 29th, 2009

According to a study from Parkville, Australia, "We have previously shown that G-CSF-deficient (G-CSF-/-) mice are markedly protected from collagen-induced arthritis ( CIA), which is the major murine model of rheumatoid arthritis, and now investigate the mechanisms by which G-CSF can promote inflammatory disease. Serum G-CSF levels were significantly elevated during CIA."

"Reciprocal bone marrow chimeras using G-CSF-/-, G-CSFR-/-, and wild-type (WT) mice identified nonhematopoietic cells as the major producers of G-CSF and hematopoietic cells as the major responders to G-CSF during CIA. Protection against CIA was associated with relative neutropenia. Depletion of...

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Source: Blood Weekly (2009-01-29)

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