Enzyme Research

Research from University of Zurich reveals new findings on enzyme research

Published in Blood Weekly, February 12th, 2009

"Glycosphingolipids (GSL) are integral components of mammalian cell membranes that are involved in cell adhesion and cell signaling processes. GSL are subdivided into structural series, like ganglio-, lacto/neolacto-, globo- and isoglo-series, which are defined by distinct trisaccharide cores," scientists writing in the journal BMC Developmental Biology report.

"The beta 1,3 N-acetylglucosaminyltransferase-V (B3gnt5) enzyme catalyzes the formation of the Lc3 structure, which is the core of lactoseries derived GSL. The biological significance of the glycoconjugates produced by the B3gnt5 enzyme was investigated by inactivating the B3gnt5 gene in the mouse...

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Source: Blood Weekly (2009-02-12)

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