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Tissue Engineering

Research from INSERM in tissue engineering provides new insights

Published in Blood Weekly, March 12th, 2009

"Articular cartilage has a low capacity for spontaneous repair. To promote the repair of this tissue, the transfer of autologous chondrocytes using a three-dimensional matrix appears promising," scientists in France report.

"In this context, the aim of the present work was to investigate the potential use of autologous rabbit nasal chondrocytes (RNC) associated with an injectable self-setting cellulose-based hydrogel (Si-HPMC). Firstly, the influence of Si-HPMC on chondrocytic phenotype was investigated by real-time PCR for specific chondrocyte markers (type 11 collagen and aggrecan) and type I collagen. Thereafter, autologous RNC were amplified in vitro for 4 weeks...

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