Transfusion Medicine

Research on transfusion medicine described by scientists at Taipei Veterans General Hospital

Published in Blood Weekly, March 12th, 2009

"Polynesian Jk(null) is well known for its mutation as Intron 5 g> a at the 3' splice acceptor site. After sequencing analysis, however, it was noticed that only three of eight samples with the Jknull phenotype carried typical homozygous Polynesian Jk(null) mutation," scientists in Taipei, Taiwan report.

"Five others were noted to be unreported heterozygous Polynesian Jk(null) mutation. An investigation was then conducted to characterize the underlying mechanism leading to this particular Jk(null) genotype. Genomic DNA covering 5'-untranslated region exons and intervening introns of the JK gene was amplified by polymerase chain reaction, and the fragments were...

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Source: Blood Weekly (2009-03-12)

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