Coagulation
Scientists at University of Amsterdam describe research in coagulation
Published in Blood Weekly, March 12th, 2009
According to recent research published in the Journal of Cellular and Molecular Medicine, "Experimental animal studies as well as clinical trials have shown that interventions targeting the blood coagulation cascade inhibit cancer cell metastasis. These data support the hypothesis that congenital prothrombotic disorders, like factor V Leiden, facilitate metastasis whereas bleeding disorders, like haemophilia impede metastasis."
"To test this hypothesis, we subjected factor V Leiden and factor VIII deficient mice to a murine model of experimental lung metastasis. In this model, B16F10 murine melanoma cells are injected into the tail vein resulting in multiple lung...
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Source: Blood Weekly (2009-03-12)
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