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Tissue Engineering

Study results from Wayne State University, Center for Molecular Medicine and Genetics broaden understanding of tissue engineering

Published in Blood Weekly, March 12th, 2009

New investigation results, 'Differential nuclear scaffold/matrix attachment marks expressed genes,' are detailed in a study published in Human Molecular Genetics. According to a study from the United States, "It is well established that nuclear architecture plays a key role in poising regions of the genome for transcription. This may be achieved using scaffold/matrix attachment regions (S/MARs) that establish loop domains."

"However, the relationship between changes in the physical structure of the genome as mediated by attachment to the nuclear scaffold/matrix and gene expression is not clearly understood. To define the role of S/MARs in organizing our genome...

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