Autoimmune Disease
New autoimmune disease study findings have been reported from University of Minnesota
Published in Blood Weekly, March 12th, 2009
According to a study from the United States, "To study retinal immunity in a defined system, a CD4(+) TCR transgenic mouse line (beta gaITCR) specific for beta-galactosidase (beta gal) was created and used with transgenic mice that expressed beta gal in retinal photoreceptor cells (arr beta gal mice). Adoptive transfer of resting beta galTCR T cells, whether naive or Ag-experienced, into arr beta gal mice did not induce retinal autoimmune disease (experimental autoimmune uveoretinitis, EAU) and gave no evidence of Ag recognition."
"Generation of beta galTCR T cells in arr beta gal mice by use of bone marrow grafts, or double-transgenic mice, also gave no retinal disease...
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Source: Blood Weekly (2009-03-12)
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