Fanconi Anemia
Study data from J.A. Lefferts and co-authors update knowledge of fanconi anemia
Published in Blood Weekly, March 19th, 2009
According to a study from the United States, "The structural protein nonerythroid alpha spectrin (alpha IISp) plays a role in the repair of DNA interstrand cross-links and is deficient in cells from patients with Fanconi anemia (FA), in which there is a defect in ability to repair such cross-links. We have proposed a model in which alpha IISp, whose stability is dependent on FA proteins, acts as a scaffold to aid in recruitment of repair proteins to sites of damage."
"In order to get a clearer understanding of the proposed. role of FA proteins in maintaining stability of alpha IISp, yeast two-hybrid analysis was carried out to determine whether FA proteins directly...
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Source: Blood Weekly (2009-03-19)
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