Hematology

New findings from University of North Carolina describe advances in hematology

Published in Blood Weekly, March 26th, 2009

According to a study from the United States, "The morbidity and mortality associated with graft-host-disease (GVHD) is a significant obstacle to the greater use of allogeneic stem cell transplantation. Donor T cells that predominantly differentiate into TH1/Tc1 T cells and generate proinflammatory cytokines such as interferon-gamma (IFN-gamma) mediate GVHD."

"Although numerous studies have described a pathogenic role for IFN-gamma, multiple reports have demonstrated that the lack of IFN-gamma paradoxically exacerbated GVHD lethality. This has led to speculation that another subset of T cells may significantly contribute to GVHD mortality. Several groups have...

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Source: Blood Weekly (2009-03-26)

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