Sickle Cell Anemia

New sickle cell anemia study findings recently were reported by researchers at Campinas State University

Published in Blood Weekly, April 2nd, 2009

"Inflammation, cell adhesion to vascular endothelium, and endothelial injury contribute to sickle cell anemia (SCA) vaso-occlusion. Although alterations in inflammatory cytokines and biomarkers have been related, reports have been conflicting, and a conclusive role for these molecules in the disease remains to be established," scientists in Campinas, Brazil report.

"Furthermore, the effect of hydroxyurea therapy (HU) on the release of inflammatory mediators is not understood. This study aimed to determine plasma levels and leukocyte gene expressions of inflammatory mediators in healthy controls, steady-state SCA patients, and SCA patients on HU therapy. TNF-alpha, IL-8,...

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Source: Blood Weekly (2009-04-02)

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