DNA Research

Research results from Royal London Hospital update knowledge of DNA research

Published in Blood Weekly, April 9th, 2009

"Complement activation plays a role in the development of chronic allograft nephropathy, a common cause of late allograft loss. The role of two complement component 3 (C3) allotypes, called C3F (fast) and C3S (slow) on the basis of their electrophoretic motility, in the long-term outcome of renal allografts remains controversial," researchers in London, the United Kingdom report.

"We selected a random sample of 1147 donor and recipient pairs from the Collaborative Transplant Study DNA bank, and their DNA specimens were genotyped for the C3F and C3S alleles. The genotyping results were analyzed according to allograft outcome. Transplants were divided into four groups,...

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Source: Blood Weekly (2009-04-09)

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