Xenotransplantion

Studies from University of Zurich have provided new data on xenotransplantion

Published in Blood Weekly, April 30th, 2009

"In pig-to-human xenotransplantation cross-species receptor interactions mediate cellular infiltration and rejection of porcine grafts. However, the mechanisms responsible for recruitment of human leukocyte subsets across porcine endothelial cells (EC) remain largely unknown," scientists in Zurich, Switzerland report.

"Here, we investigated the role of CD99, CD18, and Ga1 alpha(1,3)Gal(Gal) in this process. Adhesion and transmigration of human peripheral blood mononuclear cell (PBMC) subsets on Gal(-/-) and Gal(-/-) porcine EC (pEC) and on human EC was analyzed using a two-compartment system separated by a permeable membrane. The mechanisms of human PBMC recruitment to...

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Source: Blood Weekly (2009-04-30)

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