Kidney Transplants

Research from Y. Gorgi and co-authors yields new data on kidney transplants

Published in Blood Weekly, May 21st, 2009

"Mannose-binding lectin (MBL), a collagen-like serum protein, is a key component of innate immunity. MBL binding to carbohydrates present on pathogens mediates lectin-dependent activation of the complement pathway," scientists in Tunis, Tunisia report.

"There is growing interest in the importance of innate immunity in host defense, particularly when adaptive immunity is compromised. Three single nucleotide polymorphisms (SNPs) of the MBL gene have been described in the first exon to be associated with low MBL Serum concentrations as well as impaired MBL structure and function. Clinical studies have shown that these MBL SNPs are associated with increased susceptibility...

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Source: Blood Weekly (2009-05-21)

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