Vascular Endothelial Growth Factor
Investigators at Kyushu University release new data on vascular endothelial growth factor
Published in Blood Weekly, May 21st, 2009
"We have demonstrated that vascular endothelial growth factor (VEGF) expression is upregulated in injured vascular wall, and blockade of VEGF inhibited monocyte infiltration and neointima formation in several animal models. In the present study, we aimed to clarify relative role of two VEGF receptors, flt-1 versus flk-1/KDR, in neointima formation after injury using flt-1 tyrosine kinase-deficient (Flt-1 TK-/-) mice and soluble Flt-1(sFlt-1) gene transfer," scientists in Fukuoka, Japan report.
"Neointima formation was comparable between wild-type and Flt-1 TK-/- mice 28 days after intraluminal wire injury in femoral arteries. By contrast, neointima formation was...
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Source: Blood Weekly (2009-05-21)
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