Angiotensins

Research data from Monash University update understanding of angiotensins

Published in Blood Weekly, May 21st, 2009

"The angiotensin II type 2 receptor (AT(2)R) is implicated to be neuroprotective in stroke, although this premise has not been directly tested. Therefore, we have examined the neuroprotective effect of AT2R stimulation after intracerebroventricular administration of AT(2)R agonist CGP42112 in a conscious rat model of stroke," scientists writing in the journal Stroke report.

"Spontaneously hypertensive rats were treated with either CGP42112 (0.1 to 10 ng/kg/min intracerebroventricularly) alone or in combination with the AT(2)R antagonist PD123319 (36 ng/kg/min intracerebroventricularly) beginning 5 days before stroke induction. A focal reperfusion model of stroke...

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Source: Blood Weekly (2009-05-21)

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