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Bone Marrow

Studies from Harvard University update current data on bone marrow

Published in Blood Weekly, June 11th, 2009

According to a study from the United States, "Haematopoietic stem and progenitor cells (HSPCs) change location during development(1) and circulate in mammals throughout life(2), moving into and out of the bloodstream to engage bone marrow niches in sequential steps of homing, engraftment and retention(3-5). Here we show that HSPC engraftment of bone marrow in fetal development is dependent on the guanine-nucleotide-binding protein stimulatory a subunit (G alpha(s))."

"HSPCs from adult mice deficient in G alpha(s) (G alpha(-/-)(s)) differentiate and undergo chemotaxis, but also do not home to or engraft in the bone marrow in adult mice and demonstrate a marked inability...

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