Cyclooxygenase

Research reports from Aarhus University provide new insights into cyclooxygenase

Published in Blood Weekly, June 11th, 2009

"It was hypothesized that calcineurin inhibitors suppress vascular cyclooxygenase (COX)-2 and exert a reciprocal influence on in vivo prostacyclin and thromboxane. This could contribute to cardiovascular morbidity in transplanted patients," investigators in Aarhus, Denmark report.

"The ability of immunosuppressives to suppress vascular COX-2 expression in vitro was studied in cultured human vascular smooth muscle cells. Blood and urine samples were collected from 28 renal transplant patients before and 2, 4 and 6 h after intake of immunosuppressives and from 11 controls. ELISA was used to measure (1) plasma 6-keto-PGF(1 alpha) and TxB(2); (2) urine excretion of PGI-M...

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Source: Blood Weekly (2009-06-11)

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