Hematology

Studies from Yamagata University, Medical Department provide new data on hematology

Published in Blood Weekly, June 11th, 2009

"Protein Z is a vitamin K-dependent plasma glycoprotein that is involved in the regulation of blood coagulation. Plasma concentrations of protein Z vary widely between subjects and are greatly reduced during warfarin therapy," scientists writing in the journal Blood report.

"We developed a sensitive and quantitative assay for protein secretion using a secretory luciferase to explore the mode of secretion of protein Z compared with that of factor X. Protein Z secretion was much less efficient than factor X and was totally dependent upon added vitamin K, while factor X secretion was not. Protein Z secretion was highly sensitive to warfarin treatment of the...

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Source: Blood Weekly (2009-06-11)

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