Monoclonal Antibodies

Reports from University of Wisconsin add new data to research in monoclonal antibodies

Published in Blood Weekly, June 11th, 2009

According to recent research from the United States, "Alemtuzumab induction with 60 days of tacrolimus treatment and continuous sirolimus treatment prevented acute rejection in nine of 10 consecutive renal allograft recipients. All patients are alive with a functioning kidney graft at 27-39 months of follow-up."

"Extensive immune monitoring was performed in all patients. Alloantibody detection, cytokine kinetics assay (CKA), and trans vivo delayed-type hypersensitivity (DTH) assay were performed every 6 months showing correlation with clinical evolution. Despite alloantibody presence in five patients, eight patients remain without the need for specific treatment and...

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Source: Blood Weekly (2009-06-11)

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