Pituitary Cancer

New findings from Gunma University, Medical Department describe advances in pituitary cancer

Published in Blood Weekly, June 11th, 2009

"Mixed lineage leukemia (MLL) is a histone methyltransferase that activates gene transcription and associates with menin. In multiple endocrine neoplasia type 1 (Men1), a mutation of menin caused decreased expression of the p27(Kip1) and p18(Ink4C) genes and deregulated cell growth," scientists writing in the journal Clinical Cancer Research report.

"We hypothesized that the same pathway might be involved in sporadic pituitary adenomas. mRNA levels for MLL, Men1, p27(Kip1), and p18(Ink4C) were measured in specimens of several sporadic pituitary adenomas, and a search for clinical parameters revealed that octreotide treatment affected the level of expression of...

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Source: Blood Weekly (2009-06-11)

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