Transfusion Medicine

Research from Medical University of Vienna reveals new findings on transfusion medicine

Published in Blood Weekly, June 11th, 2009

According to recent research published in the journal Transfusion, "Platelets (PLTs) contain mRNA and synthesize proteins in response to activation. Most guidelines for PLT concentrates (PCs) recommend ambient temperature for storage but the impact of the storage temperature on PLT mRNA content has not yet been investigated."

"Ten leukoreduced apheresis PCs were split and stored at 22 and 4 degrees C. P-selectin mRNA, its expression on PLTs, and its soluble form were quantified. In parallel, cellular (cell count, mean PLT volume), metabolic (pH, pO(2), pCO(2), HCO3, glucose), and functional markers (swirling, hypotonic shock response, aggregation to collagen)...

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Source: Blood Weekly (2009-06-11)

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