Stem Cell Research
Research from University of Birmingham, Institute of Biomedical Research provides new data about stem cell research
Published in Blood Weekly, June 11th, 2009
A new study, 'Reduced c-Myb activity compromises HSCs and leads to a myeloproliferation with a novel stem cell basis,' is now available. According to a study from Edgbaston, the United Kingdom, "Murine haematopoietic stem cells (HSCs) are contained in the Kit+Sca1+Lin(-) (KSL) population of bone marrow and are able to repopulate lethally irradiated mice. Myeloproliferative disorders (MPDs) are thought to be clonogenic diseases arising at the level of the HSC."
"Here, we show that mice expressing low levels of the transcription factor c-Myb, as the result of genetic knockdown, develop a transplantable myeloproliferative phenotype that closely resembles the human disease...
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Source: Blood Weekly (2009-06-11)
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