Allograft Nephropathy

Researchers at Akita University release new data on allograft nephropathy

Published in Blood Weekly, June 11th, 2009

"We assessed reported associations of CYP3A5 *1 allele with a delay in achieving target tacrolimus concentrations, and occurrence of biopsy-confirmed subclinical acute rejection (SAR) and chronic allograft nephropathy (CAN) in Japanese subjects. Forty-one renal allograft recipients were studied," scientists writing in the European Journal of Clinical Pharmacology report.

"The targeted tacrolimus trough concentrations were 20-25 ng/mL up to 2 weeks post-transplantation, 10-15 ng/mL up to 6 weeks, and 5-10 ng/mL thereafter. At 1 month and 1 year post-transplantation, allograft biopsies were performed. The CYP3A5 *1/*1 + *1/*3 (expresser) and *3/*3 (nonexpresser)...

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Source: Blood Weekly (2009-06-11)

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