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Ebola Hemorrhagic Fever



New ebola hemorrhagic fever study findings have been reported by scientists at Boston University, Medical Department



June 18th, 2009

According to a study from the United States, "We have previously shown that the first transcription start signal (TSS) of Zaire Ebola virus ( ZEBOV) is involved in formation of an RNA secondary structure regulating VP30-dependent transcription activation. Interestingly, transcription of Marburg virus ( MARV) minigenomes occurs independently of VP30."

"In this study, we analyzed the structure of the MARV 3' noncoding region and its influence on VP30 necessity. Secondary structure formation of the TSS of the first gene was experimentally determined and showed substantial differences from the structure formed by the ZEBOV TSS. Chimeric MARV minigenomes mimicking the...


Source: Blood Weekly (2009-06-18)

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