Life Sciences

Data on life sciences reported by B.L. Esplin and co-researchers

Published in Blood Weekly, June 18th, 2009

"The recent description of a Lin(-)AA4.1(+)CD19(+)B220(Lo/-) B1-specified progenitor (B1P) population in adult marrow adds support for the argument that these unique B cells arise from a distinct lineage. However, the origins of B1P were not investigated and their developmental relationships to conventional B2 cells remain unclear," scientists in the United States report.

"We now report that B1P development is IL-7R alpha-dependent, and negatively regulated by Bruton tyrosine kinase. Lymphoid characteristics of B1P were further studied with recombination activating gene (RAG)-1/GFP knock-in, RAG-1/Cre reporter, and VEX transgenic mice. Our results reveal that they are...

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Source: Blood Weekly (2009-06-18)

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