Life Sciences
Research reports from A. Nechansky and co-authors provide new insights into life sciences
Published in Blood Weekly, June 18th, 2009
"The fully humanized Lewis-Y carbohydrate specific monoclonal antibody (mAb) IGN311 is currently tested in a passive immunotherapy approach in a clinical phase I trail and therefore regulatory requirements demand qualified assays for product analysis. To demonstrate the functionality of its Fc-region, the capacity of IGN311 to mediate complement dependent cytotoxicity (CDC) against human breast cancer cells was evaluated," scientists in Vienna, Austria report.
"The ''classical'' radioactive method using chromium-51 and a FACS-based assay were established and qualified according to ICH guidelines. Parameters evaluated were specificity, response function, bias,...
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Source: Blood Weekly (2009-06-18)
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