Neovascularization
New neovascularization study findings recently were published by researchers at University of Bristol
Published in Blood Weekly, June 25th, 2009
According to a study from Bristol, the United Kingdom, "Human Tissue Kallikrein (hKLK1) overexpression promotes an enduring neovascularization of ischemic tissue, yet the cellular mechanisms of hKLK1-induced arteriogenesis remain unknown. Furthermore, no previous study has compared the angiogenic potency of hKLK1, with its loss of function polymorphic variant, rs5515 (R53H), which possesses reduced kinin-forming activity."
"Here, we demonstrate that tissue kallikrein knockout mice (KLK1(-/-)) show impaired muscle neovascularization in response to hindlimb ischemia. Gene-transfer of wild-type Ad.hKLK1 but not Ad.R53H-hKLK1 was able to rescue this defect. Similarly, in...
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Source: Blood Weekly (2009-06-25)
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