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Alpha-thalassemia

New research on alpha-thalassemia from University of Malaya, Medical Department summarized

Published in Blood Weekly, June 25th, 2009

According to recent research from Kuala Lumpur, Malaysia, "Co-inheritance of alpha-thalassemia with homozygosity or compound heterozygosity for beta-thalassemia may ameliorate beta-thalassemia major. A wide range of clinical phenotypes is produced depending on the number of beta-thalassemia alleles (-alpha(alpha alpha--/alpha alpha, --/-alpha)."

"The co-inheritance of beta-thalassemia with a-thalassemia with a single gene deletion (-alpha/alpha) is usually associated with thalassemia major. In contrast, the co-inheritance of beta-thalassemia with two alpha-genes deleted in cis or trans (--/alpha alpha or -alpha/-alpha) generally produces beta-thalassemia intermedia. In...

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