Acute Myelogenous Leukemia

Studies from University of Pittsburgh update current data on acute myelogenous leukemia

Published in Blood Weekly, July 9th, 2009

"Regulatory CD4(+)CD25(high)Foxp3(+) T cells (Treg) control peripheral immune tolerance. Patients with cancer, including those with hematologic malignancies, have elevated numbers of Treg in the peripheral circulation and in tumor tissues," investigators in the United States report.

"However, mechanisms of suppression and clinical significance of Treg, especially in patients with acute myelogenous leukemia (AML), has not been well defined. We prospectively evaluated the phenotype, function, and mechanisms of suppression used by Treg in newly diagnosed untreated AML patients. The relationship between the frequency of circulating Treg and the disease status as well as...

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Source: Blood Weekly (2009-07-09)

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