Published in Blood Weekly, July 23rd, 2009
"We propose a novel TPMT-mediated mechanism of S-adenosylmethionine (SAM)-specific effects on 6-mercaptopurine (6-MP) induced cytotoxicity in a model cell line for acute lymphoblastic leukemia (MOLT). Our results show that exogenous SAM (10-50 mc M) rescues cells from the toxic effects of 6-MP (5 mc M) by delaying the onset of apoptosis. We prove that the extent of...
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