Leukemia

Researchers from Ehime University describe findings in leukemia

Published in Blood Weekly, July 23rd, 2009

"Curcumin reportedly has anti-allergic effects and can inhibit the release of histamine from mast cells. In the present study, fourteen benzylidenecyclopentanone analogues of curcumin were studied for their effects on histamine release from rat basophilic leukemia (RBL-2H3) cells," investigators in Japan report.

"After screening, four selected compounds: 2,5-bis(4-hydroxybenzylidene)cyclopentan one; 2,5-bis(4-hydroxy-3-methoxybenzylidene)cyclopentanone; 2,5-bis(4-hydroxy-3,5-dimethylbenzylidene) cyclopentanone; and 2,5-bis(4-hydroxy-3,5-diethylbenzylidene)cyclo pen tan one were studied for their concentration-dependent effects on histamine release and Ca2+ uptake. In...

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Source: Blood Weekly (2009-07-23)

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