Thrombosis Cell Biology

New thrombosis cell biology data have been reported by investigators at University of Wurzburg, DFG Research Center for Experimental Biomedicine

Published in Blood Weekly, July 23rd, 2009

Research findings, 'Calcium signaling in platelets,' are discussed in a new report. According to recent research published in the Journal of Thrombosis and Haemostasis, "Agonist-induced elevation in cytosolic Ca2+ concentrations is essential for platelet activation in hemostasis and thrombosis. It occurs through Ca2+ release from intracellular stores and Ca2+ entry through the plasma membrane (PM)."

"Ca2+ store release is a well-established process involving phospholipase (PL)C-mediated production of inositol-1,4,5-trisphosphate (IP3), which in turn releases Ca2+ from the intracellular stores through IP3 receptor channels. In contrast, the mechanisms controlling...

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Source: Blood Weekly (2009-07-23)

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