Leukemia Gene Therapy
Research on leukemia gene therapy published by scientists at Glasgow Caledonian University
Published in Blood Weekly, August 6th, 2009
According to a study from Scotland, "The emergence of leukemia following gene transfer to restore common cytokine receptor gamma chain (gamma C) function in X-linked severe combined immunodeficiency (SCID-X1) has raised important questions with respect to gene therapy safety. To explore the risk factors involved, we tested the oncogenic potential of human gamma C in new strains of transgenic mice expressing the gene under the control of the CD2 promoter and locus control region (LCR)."
"These mice demonstrated mildly perturbed T-cell development, with an increased proportion of thymic CD8 cells, but showed no predisposition to tumor development even on highly tumor...
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Source: Blood Weekly (2009-08-06)
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