HIV/AIDS

Researchers from National Heart, Lung, & Blood Institute publish findings in HIV/AIDS

Published in Blood Weekly, August 13th, 2009

"Inherited disorders of globin synthesis remain desirable targets for hematopoietic stem cell (HSC)-based therapies. Gene transfer using retroviral vectors offers an alternative to allogeneic HSC transplantation by the permanent integration of potentially therapeutic genes into primary autologous HSCs," investigators in the United States report.

"Although proof of principle has been demonstrated in humans, this approach has been met by formidable obstacles, and large-animal models have become increasingly important for the preclinical development of gene addition strategies. Here we report lentiviral gene transfer of the human beta-globin gene under the control of the...

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Source: Blood Weekly (2009-08-13)

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