Sepsis

Research conducted at University of Sao Paulo has updated our knowledge about sepsis

Published in Blood Weekly, August 13th, 2009

"Sepsis is a systemic inflammatory response resulting from the inability of the host to contain the infection locally. Previously, we demonstrated that during severe sepsis there is a marked failure of neutrophil migration to the infection site, which contributes to dissemination of infection, resulting in high mortality," scientists in Sao Paulo, Brazil report.

"IL-17 plays an important role in neutrophil recruitment. Herein, we investigated the role of IL-17R signaling in polymicrobial sepsis induced by cecal ligation and puncture (CLP). It was observed that IL-17R-deficient mice, subjected to CLP-induced non-severe sepsis, show reduced neutrophil recruitment into the...

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Source: Blood Weekly (2009-08-13)

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