Published in Blood Weekly, August 13th, 2009
"We therefore determined the effects of moderate hypercapnia on markers of systemic and splanchnic oxidative metabolism in an animal model of endotoxemia. Anesthetized rats maintained at a PaCO2 of 30, 40 or 60 mmHg were challenged with endotoxin. A control group (PaCO2 40 mmHg) received isotonic saline. Hemodynamic variables, arterial lactate, pyruvate, and ketone bodies were measured at baseline and after 4 h. Tissue...
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