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Perfusion

Reports from St. Thomas' Hospital advance knowledge in perfusion

Published in Blood Weekly, August 20th, 2009

According to recent research published in the journal Cardiovascular Research, "Despite their ability to cause septic shock and myocardial dysfunction, components of Gram-negative bacterial cell walls, like lipopolysaccharide, have been shown in numerous studies to induce myocardial protection during ischaemia-reperfusion injury. Muramyl dipeptide (MDP) is another such component recognized by an intracellular receptor, nucleotide-binding oligomerization domain 2. Receptor activation leads to intracellular signals through receptor interacting protein-2 (RIP2) and tumour growth factor-beta-activated kinase-1 (TAK1)."

"However, little is known about the RIP2/TAK1...

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