Transfusion Medicine
New transfusion medicine study findings have been published by E. Strobel and colleagues
Published in Blood Weekly, September 3rd, 2009
According to recent research published in the journal Transfusion Medicine, "Cross-reactivities of monoclonal reagents for red blood cell (RBC) typing are seen very rarely, e.g. in some reagents for testing of ABO or Lewis antigens. We report on two patients in whom we observed weak reactions using a monoclonal anti-c reagent containing clone MS35, but no reactions with anti-c reagents containing other monoclonal or polyclonal antibodies."
"To resolve this discrepancy, we studied RHCE exon 1 (Ex1) and 2 from genomic DNA of one patient and performed quality controls of the false-positive reacting anti-c reagent. RHCE Ex1 showed no abnormalities as well as RH Ex2...
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Source: Blood Weekly (2009-09-03)
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