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Renal Disease

Research on renal disease detailed by K. Pawlak and co-authors

Published in Blood Weekly, September 10th, 2009

According to a study from Bialystok, Poland, "With end-stage renal disease (ESRD) exhibit features of a hypercoagulable state, which may contribute to atherosclerosis. Kynurenines are the metabolites of tryptophan degradation in mammals."

"We examined the relationship between coagulation activation and kynurenines in 92 patients with ESRD on maintenance haemodialysis (HD) or continuous ambulatory peritoneal dialysis (CAPD) and 20 healthy controls. We measured the plasma levels of. tissue factor (TF), its pathway inhibitor (TFPI), the marker of coagulation activation - prothrombin fragments 1+2 (F1+2), kynurenine (KYN) and its metabolites: kynurenic (KYNA), anthranilic...

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