Apoptosis

Data from C. Agakidis and colleagues advance knowledge in apoptosis

Published in Blood Weekly, September 17th, 2009

According to a study from Thessaloniki, Greece, "Despite the widespread use of antenatal glucocorticosteroids (GCs), the possibility of adverse effects on the immune response in preterm neonates remains a major concern. GCs stimulate lymphocyte apoptosis, resulting in lymphopenia and functional disorders, which have been associated with sepsis-related death in critically ill neonates."

"We sought to assess the effect of antenatal betamethasone (BM) on lymphocyte apoptosis in preterm neonates. Fifty preterm neonates exposed to antenatal BM and 50 controls were studied prospectively. Lymphocyte apoptosis was assessed using the annexin-V/propidium iodide (PI) assay,...

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Source: Blood Weekly (2009-09-17)

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