Apoptosis

Studies from Louisiana State University yield new information about apoptosis

Published in Blood Weekly, September 17th, 2009

According to a study from the United States, "Apoptosis of lymphocytes is important in the termination of an immune response to infection but has also been shown to have detrimental effects in animal models of systemic infection and sepsis. We sought to characterize lymphocyte apoptosis in an animal model of pneumonia due to Pneumocystis murina, an infection localized to the lungs."

"Control mice and mice depleted of CD4+ lymphocytes were inoculated with Pneumocystis. Apoptosis of lung and spleen lymphocytes was assayed by flow cytometry and PCR assay of apoptotic proteins. In control mice, apoptosis of lung lymphocytes was maximal just after the infection was cleared...

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Source: Blood Weekly (2009-09-17)

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