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Mental Retardation

Scientists at INSERM discuss research in mental retardation

Published in Blood Weekly, September 24th, 2009

According to a study from Paris, France, "Contrepas A, Walker J, Koulakoff A, Franek KJ, Qadri F, Giaume C, Corvol P, Schwartz CE, Nguyen G. A role of the (pro)renin receptor in neuronal cell differentiation. Am J Physiol Regul Integr Comp Physiol 297: R250-R257, 2009."

"First published May 27, 2009; doi:10.1152/ajpregu.90832.2008.-The (pro)renin receptor [(P)RR] plays a pivotal role in the renin-angiotensin system. Experimental models emphasize the role of (P)RR in organ damage associated with hypertension and diabetes. However, a mutation of the (P)RR gene, resulting in frame deletion of exon 4 [Delta 4-(P)RR] is associated with X-linked mental retardation (XLMR) and...

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