B-Cell Lymphoma
Studies from J. Wei and colleagues yield new information about B-cell lymphoma
Published in Blood Weekly, September 24th, 2009
"Guided by nuclear magnetic resonance (NMR) binding assays and computational docking studies, a series of 5,5' substituted apogossypol derivatives was synthesized that resulted in potent pan-active inhibitors of antiapoptotic Bcl-2 family proteins. Compound 8r inhibits the binding of BH3 peptides to Bcl-X-L, Bcl-2, Mcl-1, and Bfl-1 with IC50 values of 0.76, 0.32, 0.28, and 0.73 mc M, respectively," scientists writing in the Journal of Medicinal Chemistry report.
"The compound also potently inhibits cell growth of human lung cancer and BP3 human B-cell lymphoma cell lines with EC50 values of 0.33 and 0.66 mc M, respectively. Compound 8r shows little cytotoxicity...
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Source: Blood Weekly (2009-09-24)
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