Squamous Cell Carcinoma
Study findings from Osaka University broaden understanding of squamous cell carcinoma
Published in Blood Weekly, October 8th, 2009
According to recent research from Suita, Japan, "Myeloid cell leukemia-1(Mcl-1), a member of the B-cell lymphoma-2 (Bcl-2) family, has been reported to be a critical survival factor in hematopoietic cells, yet little data exists for a role of Mcl-1 in human oral squamous cell carcinoma (SCC). A high level expression of Mcl-1 was observed in tumor cells of human primary SCC, lymph node metastasis tissues, and SCC cell lines."
"We manipulated expression of Mcl-1 protein in SCC cells by small interfering RNA (siRNA) for Mcl-1 and observed that Mcl-1 siRNA inhibited the growth of SCCs accompanied with apoptosis. Combination therapy of Mcl-1 siRNA and anti-tumor drug...
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Source: Blood Weekly (2009-10-08)
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