Stem Cell Research

Scientists at Seoul National University report research in stem cell research

Published in Blood Weekly, November 12th, 2009

According to a study from Seoul, South Korea, "Interleukin-17 (IL-17) is a cytokine secreted primarily by TH-17 cells. Although IL-17 is primarily associated with the induction of tissue inflammation, the other biological roles of IL-17, including non-immune functions, have yet to be thoroughly explored."

"Here, we report that T-cell-produced IL-17 can induce proliferation of human bone marrow-derived mesenchymal stem cells (hMSCs) in a manner dependent on the generation of reactive oxygen species (ROS). Rac1 GTPase and NADPH oxidase 1 (Nox1) are activated by IL-17 to produce ROS, which in turn stimulates hMSC proliferation. The activation of the MEK-ERK pathway is also...

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Source: Blood Weekly (2009-11-12)

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