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Journal of the National Cancer Institute

Erythropoiesis-stimulating agents associated with higher risk of venous thromboembolism

Published in Blood Weekly, November 26th, 2009

Use of erythropoiesis-stimulating agents is associated with an increased risk of venous thromboembolism, according to study published online November 10 in the Journal of the National Cancer Institute.

Erythropoiesis-stimulating agents (i.e., erythropoietin and darbopoietin) stimulate red blood cell production and therefore were approved to reduce the number of blood transfusions required during chemotherapy; however, concerns about the risks of venous thromboembolism (the disease that includes deep vein thrombosis and pulmonary embolism) and mortality exist.

Dawn L. Hershman, M.D., of Columbia University Medical Center in New York, and colleagues...

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