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Thrombasthenia

Studies from M. Kannan and co-researchers in the area of thrombasthenia published

Published in Blood Weekly, December 3rd, 2009

According to a study from New Delhi, India, "Glanzmann thrombasthenia (GT) is an autosomal recessive inherited platelet function defect that is characterized by reduction in, or absence of, platelet aggregation in response to multiple physiologic agonists. The defect is caused by mutations in the genes encoding ITGA2B or ITGB3."

"This results in qualitative or quantitative abnormalities of the platelet receptor, alpha IIb-beta 3. The aim of this study was to identify the mutations in GT patients and to correlate these with patient phenotype. A total of 45 unrelated patients with GT were enrolled in the present study to identify the causative molecular defects, and also...

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