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Allograft Nephropathy

Research from University of Duisburg-Essen in the area of allograft nephropathy described

Published in Blood Weekly, December 3rd, 2009

"The purpose of this study was to analyse the outcome and its influencing factors in patients whose therapy was converted from calcineurin inhibitors (CNI) to sirolimus (SRL) due to chronic allograft nephropathy (CAN). Therapies of 78 patients (44 men) with CAN from three European transplant centres were converted from CNI therapy to SRL and followed 24 months," scientists in Essen, Germany report.

"Slopes for creatinine clearance before and after conversion were calculated. Influencing factors were analysed by a multivariance analysis. The slope of the creatinine clearance improved significantly (-0.90 vs. -0.34 ml min(-1) month(-1); p< 0.01). In patients whose...

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