Lymphoma

Studies from INSERM have provided new information about lymphoma

Published in Blood Weekly, December 24th, 2009

According to a study from Paris, France, "The spectrum of tumors showing microisatellite instability (MSI) has recently been enlarged to sporadic neoplasms whose incidence is favored In the context (if chronic immunosuppression. We investigated (lie biological, therapeutic and clinical features associated with MSI in immunodeficiency- related non-Ilodgkin lymphomas (ID-RL)."

"MSI screening was performed in 275 ID-RL MSI ID-RL, were further analyzed for MMR gene expression and for BRAF/KRAS mutations since these genes are frequently altered fit MSI cancers. We also assessed the expression of O-methylguanine-DNA methyltransferase(MGMT), an enzyme whose inactivation has...

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Source: Blood Weekly (2009-12-24)

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