Life Sciences

Researchers from Tufts University, Medical Department detail findings in life sciences

Published in Blood Weekly, December 31st, 2009

"RIP is a novel antibiotic against staphylococci. It acts at least in part by competing with RNAI activating protein (RAP) by downregulating TRAP histidine phosphorylation, and by downregulating the expression of the Acessory Gene Regulator (agr)," researchers in the United States report.

"While much is known about the function of the agr as a quorum sensing system that regulates virulence, not much is known about TRAP. TRAP is a 167-kDa protein that is highly conserved among staphylococci and is involved in DNA protection from stress. TRAP is membrane-associated but does not have a transmembrane domain, and thus it may be bound to the membrane through other proteins....

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Source: Blood Weekly (2009-12-31)

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